Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections.

Academic Article


  • OBJECTIVE: The objective of this investigation was to establish the safety of high-dose (HD) acyclovir for the treatment of neonatal herpes simplex virus (HSV) disease. In addition, an estimate of therapeutic efficacy was sought, both with respect to mortality and to morbidity. Virologic efficacy of HD acyclovir was also assessed. PARTICIPANTS: Infants who were
  • Published In

  • Pediatrics  Journal
  • Keywords

  • Acyclovir, Drug Administration Schedule, Herpes Simplex, Humans, Infant, Newborn, Infusions, Intravenous, Injections, Intravenous
  • Digital Object Identifier (doi)

    Author List

  • Kimberlin DW; Lin CY; Jacobs RF; Powell DA; Corey L; Gruber WC; Rathore M; Bradley JS; Diaz PS; Kumar M
  • Start Page

  • 230
  • End Page

  • 238
  • Volume

  • 108
  • Issue

  • 2