Oseltamivir dosing for influenza infection in premature neonates

Academic Article


  • Under the Emergency Use Authorization issued in April 2009, oseltamivir can be used to treat 2009 influenza A (H1N1) virus infection in children aged <1 year. No data exist on the dosing of oseltamivir in premature babies. A hospital health care worker inadvertently exposed 32 neonatal intensive care unit babies to 2009 influenza A (H1N1); a protocol was expeditiously implemented to collect samples for pharmacokinetics and dosage evaluation. Results suggest 1.0 mg/kg/dose twice daily in premature babies produces oseltamivir carboxylate exposures similar to that in older children receiving 3.0 mg/kg/dose twice daily. These results provide initial guidance on dosing oseltamivir in this vulnerable population. © 2010 by the Infectious Diseases Society of America.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Acosta EP; Jester P; Gal P; Wimmer J; Wade J; Whitley RJ; Kimberlin DW
  • Start Page

  • 563
  • End Page

  • 566
  • Volume

  • 202
  • Issue

  • 4