Objectives: To describe the development and application of an organizing research framework to guide Children's Oncology Group (COG) nursing research. Data Sources: Research articles, reports and meeting minutes. Conclusion: An organizing research framework helps to outline research focus and articulate the scientific knowledge being produced by nurses in the pediatric cooperative group. Implications for Nursing Practice: The use of a COG nursing research organizing framework can facilitate the clinical nurse's understanding of how children and families sustain or regain optimal health when faced with a pediatric cancer diagnosis through interventions designed to promote individual and family resilience. © 2014 Elsevier Inc.