Effector and regulatory B cells: Modulators of CD4+ T cell immunity

Academic Article


  • B cells are essential for humoral immunity, but the role that they have in regulating CD4+ T cell responses remains controversial. However, new data showing that the transient depletion of B cells potently influences the induction, maintenance and reactivation of CD4+ T cells, with the recent identification of antibody-independent functions of B cells, have reinvigorated interest in the many roles of B cells in both infectious and autoimmune diseases. In this Review, we discuss recent data showing how effector and regulatory B cells modulate CD4+ T cell responses to pathogens and autoantigens. © 2010 Macmillan Publishers Limited. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Lund FE; Randall TD
  • Start Page

  • 236
  • End Page

  • 247
  • Volume

  • 10
  • Issue

  • 4