Autoimmunity and increased c-myb transcription

Academic Article


  • A single recessive gene, 1pr, induces an autoimmune-lymphoproliferative syndrome in several strains of mice. The lymphoid organs of 1pr/1pr mice contained cells with increased amounts of myb RNA, which codes for a protein found in the nucleus. A similar human lymphoproliferative disorder also had an increase in c-myb expression. Mouse T cells induced by mitogens to proliferate did not express large amounts of myb RNA, indicating that marked myb expression is not a general feature of lymphocyte activation and proliferation.
  • Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 26386997
  • Author List

  • Mountz JD; Steinberg AD; Klinman DM; Smith HR; Mushinski JF
  • Start Page

  • 1087
  • End Page

  • 1089
  • Volume

  • 226
  • Issue

  • 4678