R/qtlbim: QTL with Bayesian Interval Mapping in experimental crosses

Academic Article

Abstract

  • Summary: R/qtlbim is an extensible, interactive environment for the Bayesian Interval Mapping of QTL, built on top of R/qtl (Broman et al., 2003), providing Bayesian analysis of multiple interacting quantitative trait loci (QTL) models for continuous, binary and ordinal traits in experimental crosses. It includes several efficient Markov chain Monte Carlo (MCMC) algorithms for evaluating the posterior of genetic architectures, i.e. the number and locations of QTL, their main and epistatic effects and gene-environment interactions. R/qtlbim provides extensive informative graphical and numerical summaries, and model selection and convergence diagnostics of the MCMC output, illustrated through the vignette, example and demo capabilities of R (R Development Core Team 2006). © 2007 Oxford University Press.
  • Authors

    Published In

  • Bioinformatics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Yandell BS; Mehta T; Banerjee S; Shriner D; Venkataraman R; Moon JY; Neely WW; Wu H; von Smith R; Yi N
  • Start Page

  • 641
  • End Page

  • 643
  • Volume

  • 23
  • Issue

  • 5