Interferon immunosuppression: Mediation by a suppressor factor

Academic Article


  • Suppression of the in vitro antibody response to sheep erythrocytes by mouse fibroblast interferon occurred by induction of suppressor cell activity in spleen cells. The suppressor cells produced a soluble factor which mediated the immunosuppression. The suppressor factor did not inhibit virus replication; thus, interferon probably regulates the B-cell response by a mechanism that is different from its antiviral effect.
  • Published In

    Author List

  • Johnson HM; Blalock JE
  • Start Page

  • 301
  • End Page

  • 305
  • Volume

  • 29
  • Issue

  • 2