Endothelium-derived ET-1 and the development of renal injury

Academic Article


  • The role of the vasoactive peptide endothelin-1 (ET-1) in renal injury is not fully understood. In this review, we examine the genetic models available to understand the autocrine/paracrine mechanisms by which ET-1 leads to renal injury and propose the working hypothesis that endothelium-derived ET-1 induces renal injury by initiating renal tubular apoptosis in a paracrine manner.
  • Digital Object Identifier (doi)

    Pubmed Id

  • 20480486
  • Author List

  • de Miguel C; Pollock DM; Pollock JS
  • Start Page

  • R1071
  • End Page

  • R1073
  • Volume

  • 309
  • Issue

  • 9