Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubule

Academic Article


  • Gene mutations in WNK4 kinase cause a genetic form of hypertension by affecting multiple ion transport pathways through different mechanisms. Cai et al. report that the inhibitory effect of WNK4 on the thiazide-sensitive sodium-chloride cotransporter occurs through the lysosomal degradation pathway in mammalian cells. © 2006 International Society of Nephrology.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Peng JB; Bell PD
  • Start Page

  • 2116
  • End Page

  • 2118
  • Volume

  • 69
  • Issue

  • 12