Channel gating regulation by the cystic fibrosis transmembrane conductance regulator (CFTR) first cytosolic loop

Academic Article


  • Background: Elucidating the mechanochemistry of ABC transporters is essential for understanding several human disease states. Results: We show a novel intermolecular binding step that governs CFTR channel activity. Conclusion: CFTR gating and ATP hydrolysis require a properly configured transmembrane domain interface. Significance: These findings indicate a new approach for discovering therapeutic targets within ABC proteins that modulate function.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 22932861
  • Author List

  • Ehrhardt A; Chung WJ; Pyle LC; Wang W; Nowotarski K; Mulvihill CM; Ramjeesingh M; Hong J; Velu SE; Lewis HA
  • Start Page

  • 1854
  • End Page

  • 1865
  • Volume

  • 291
  • Issue

  • 4