HIV type 1 abrogates TAP-mediated transport of antigenic peptides presented by MHC class I

Academic Article

Abstract

  • Downregulation of MHC class I expression following human immunodeficiency virus 1 (HIV-1) infection is thought to play an important role in viral escape from immune recognition by cytotoxic T-lymphocytes (CTLs). Since exogenous addition of HIV-1-derived peptides restores susceptibility of HIV-1-infected cells to CTL-mediated lysis, we tested whether endogenous peptide loading is impaired in these cells. Our results show that in HIV-1-infected cells the ability of the transporter associated with antigen presentation (TAP) to translocate antigenic peptides from the cytosol to the lumen of the ER for presentation on MHC class I molecules is abolished. These data suggest that interference with the supply of antigenic peptides to the MHC class I pathway provides an additional mechanism by which HIV-1 evades the CTL-mediated immune response.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Kutsch O; Vey T; Kerkau T; H√ľnig T; Schimpl A
  • Start Page

  • 1319
  • End Page

  • 1325
  • Volume

  • 18
  • Issue

  • 17