The role of dysfunctional HDL in atherosclerosis

Academic Article


  • This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity. Copyright ©2009 by the American Society for Biochemistry and Molecular Biology, Inc.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Navab M; Reddy ST; Van Lenten BJ; Anantharamaiah GM; Fogelman AM
  • Volume

  • 50
  • Issue

  • SUPPL.