Patient preferences for novel therapy - An N-of-1 trial of garlic in the treatment for hypertension

Academic Article


  • The authors used the N-of-1 clinical trial methodology to obtain insights about a patient's preference for garlic for the management of his hypertension. The 61-year-old man received garlic, 500 mg by mouth three times a day (3 weeks), or identical placebo (3 weeks) in three treatment pairs. While the patient was taking garlic the mean systolic blood pressure decreased by 2 mm Hg (95% confidence interval 0.4 to 4.7, p<0.05), and the diastolic blood pressure decreased by 2.4 mm Hg (95% confidence interval 0.4 to 4, p<0.025). The treatment effect of garlic was small, but the patient believed continuing garlic for the management of his hypertension was justified. © 1993 Society of General Internal Medicine.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Estrada CA; Young MJ
  • Start Page

  • 619
  • End Page

  • 621
  • Volume

  • 8
  • Issue

  • 11