Cross-species complementation of the indispensable Escherichia coli era gene highlights amino acid regions essential for activity

Academic Article


  • Era is an essential GTP binding protein in Escherichia coli. Two homologs of this protein, Sgp from Streptococcus mutans and Era from Coxiella burnetii, can substitute for the essential function of Era in E. coli. Site- specific and randomly generated Era mutants which may indicate regions of the protein that are of functional importance are described.
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    Author List

  • Pillutla RC; Sharer JD; Gulati PS; Wu E; Yamashita Y; Lerner CG; Inouye M; March PE
  • Start Page

  • 2194
  • End Page

  • 2196
  • Volume

  • 177
  • Issue

  • 8