Predictors of Survival in Patients With End-Stage Renal Disease Evaluated for Kidney Transplantation

Academic Article


  • Cardiovascular disease is the major cause of mortality in patients with end-stage renal disease (ESRD). This study examined the all-cause mortality in 3,698 patients with ESRD evaluated for kidney transplantation at our institution from 2001 to 2004. Mean age for the cohort was 48 ± 12 years, and 42% were women. Stress myocardial perfusion imaging was done in 2,207 patients (60%) and coronary angiography in 260 patients (7%). There were 622 deaths (17%) during a mean follow-up period of 30 ± 15 months. The presence and severity of coronary disease on angiography was not predictive of survival. Coronary revascularization did not impact survival (p = 0.6) except in patients with 3-vessel disease (p = 0.05). The best predictor of death was left ventricular ejection fraction, measured by gated myocardial perfusion imaging, with 2.7% mortality increase for each 1% ejection fraction decrease. In conclusion, left ventricular ejection fraction is a strong predictor of survival in patients with ESRD awaiting renal transplantation. Strategies to improve cardiac function or earlier renal transplantation deserve further studies. © 2007 Elsevier Inc. All rights reserved.
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    Digital Object Identifier (doi)

    Author List

  • Hage FG; Smalheiser S; Zoghbi GJ; Perry GJ; Deierhoi M; Warnock D; Iskandrian AE; de Mattos AM; Aqel RA
  • Start Page

  • 1020
  • End Page

  • 1025
  • Volume

  • 100
  • Issue

  • 6