The revised and updated 2nd Edition provides a logical, practical framework for managing patients with hypertension. Todays leading experts discuss all aspects of the fieldfrom pathophysiology, pharmacological treatments, and lifestyle modifications to secondary hypertension and cardiovascular complications. Assesses the risks of specific pharmacological treatments * offers expert analysis of recent clinical trials * and provides Delivers strategies for managing patients with comorbid conditions such as diabetes, renal disease, and ischemic heart disease. Explains the role of vascular biology in the pathogenesis of hypertension. Includes 11 new chapters: The National High Blood Pressure Education Program * Angiotensin 1-7 * Aldosterone and Minealocorticoids * Vasodilator Peptides * Clinical Outcome Trials of Hypertension with Angiotensin Receptor Blockers * ACE Inhibitor Trials: Effects in Hypertension * Obesity and Hypertension: Role of Diet Drugs * Exercise and Hypertension * Pharmacokinetics of Antihypertensive Drugs * Hypertension in Children * and Dietary Approaches to Hypertension Management: The DASH Studies. Provides complete revisions of all other existing chapters. Features new clinical pearls * evidence-based therapeutic ladders that summarize key therapy regimens * and preferred treatment boxes that highlight important information. © 2005 Elsevier Inc. All rights reserved.