This special issue of the Journal of Integrated Design and Process Science is intended to generate new knowledge as well as provocative research questions. Application is showcased in several articles. This collection of papers permits researchers throughout the world to gain insight and understanding of what others are doing in their fields and possibilities for future study. The research landscape for STEM fields is undergoing especially dramatic and rapid change. Universities, governments, and private sector enterprises are funding research endeavors to capitalize on existing knowledge and new developments. Furthermore, applied research is coming under the spotlight. Increasingly our technological developments are enabling research to move quickly beyond the theoretical into real-world applications.