Long-cycle structured intermittent versus continuous highly active antiretroviral therapy for the treatment of chronic infection with human immunodeficiency virus: Effects on drug toxicity and on immunologic and virologic parameters

Academic Article


  • We evaluated the effect of long-cycle structured intermittent therapy (SIT; 4 weeks without highly active antiretroviral therapy [HAART] followed by 8 weeks with HAART) versus continuous HAART. The study was prematurely terminated to new enrollment because of the emergence of genetic mutations associated with resistance to antiretroviral drugs in 5 patients. After 48 weeks, there was no significant difference between groups in lipid, hepatic transaminase, and C-reactive protein levels in 41 patients. Although there were no differences in CD4+ or CD8+ T cell counts or the percentage of cells that were CD4+CD25+, CD8+CD25+, or CD4+DR+, patients who received SIT had a significantly higher percentage of CD8+CD38+ and CD8+DR+ cells. There was no clear autoimmunization effect by immunologic or virologic parameters. There was no benefit to long-cyde SIT versus continuous HAART with regard to certain toxicity, immunologic, or virologic parameters.
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    Author List

  • Dybul M; Nies-Kraske E; Daucher M; Hertogs K; Hallahan CW; Csako G; Yoder C; Ehler L; Sklar PA; Belson M
  • Start Page

  • 388
  • End Page

  • 396
  • Volume

  • 188
  • Issue

  • 3