Objectives: To examine the contribution of social cognitive constructs to meeting physical activity (PA) recommendations in rural breast cancer survivors (BCS). Methods: Rural BCS (N = 483) completed a mailbased survey. PA, fatigue, barriers and exercise self-efficacy, environment, social support, and perceived barriers to PA were assessed. PA was dichotomized into either meeting guidelines (150+minutes/week) or not. Results: Our model fit the data well with less fatigue, greater efficacy, and lower barriers being associated with PA (χ2=804.532(418), p < .001, CFI=.948, RMSEA=.044, SRMR=.046). Conclusions: Fatigue, self-efficacy, and perceived barriers are key targets for future interventions designed to increase PA in rural BCS. Enhancing self-efficacy and overcoming barriers will require strategies unique and relevant to BCS living in rural settings.