This chapter discusses design for fiber-reinforced polymer (FRP)/autoclaved aerated concrete (AAC) sandwich panels for structural applications. The chapter first presents the finite element analysis (FE) of FRP/AAC panels. The FE results are compared with the experimental results showing acceptable agreement. Next, analytical models are presented to predict the deflection and strength of the panels. Finally, design graphs have been developed to help in designing the floor and wall panels made from FRP/AAC panels. Also, those panels have been compared to the commercially used reinforced AAC panels demonstrating that FRP/AAC panels offer a relatively cost-effective solution for longer life cycle.