Objective: To evaluate potential associations among condom errors and gonorrhea and chlamydial infection among a population of sexually transmitted disease clinic patients. Methods: Audio computer-assisted self- interviewing was used to conduct a cross-sectional survey with 1124 participants. Biological specimens were collected during the evaluation visit. Results: A substantial proportion of participants reported condom-use errors with condom breakage statistically associated with gonorrhea infection among males at enrollment (AOR=1.91; 95% CI: 123-2.96; P=.004). Conclusion: Behavioral interventions that promote consistent condom use must provide the necessary skills associated with proper condom use.