Interstitial Collagen Loss, Myocardial Remodeling, and Function in Primary Mitral Regurgitation

Academic Article


  • Interstitial collagen loss and cardiomyocyte ultrastructural damage accounts for left ventricular (LV) sphericity and decrease in LV twist and circumferential strain. Normal LV diastolic function belies significantly abnormal left atrial (LA) function and early LV diastolic untwist rate. This underscores the complex interplay of LV and LA myocardial remodeling and function in the pathophysiology of primary mitral regurgitation. In this study, we connect LA function with LV systolic and diastolic myocardial remodeling and function using cardiac magnetic resonance tissue tagging in primary mitral regurgitation.
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    Digital Object Identifier (doi)

    Author List

  • Ahmed MI; Andrikopoulou E; Zheng J; Ulasova E; Pat B; Kelley EE; Powell PC; Denney TS; Lewis C; Davies JE
  • Start Page

  • 973
  • End Page

  • 981
  • Volume

  • 7
  • Issue

  • 10