A new generation of high flex life polyurethane urea for polymer heart valve - Studies on in vivo biocompatibility and biodurability

Academic Article


  • Development of new generation high flex life polyurethane urea (HFL18-PU) with appropriate elastic modulus, biocompatibility, blood compatibility, resistant to calcification, and biodurability for the long-term use as cardiac device is still a challenge. This study reports the development of a fully aliphatic, ether-free physically cross-linked and low elastic modulus (6.841 ± 0.27 MPa) polyurethane urea having in vivo biostability, in vivo biocompatibility and high flex-life (721 ± 30 million cycles) that can satisfy the requirements for the fabrication of tri-leaflet heart valve. © 2008 Wiley Periodicals, Inc.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Thomas V; Jayabalan M
  • Start Page

  • 192
  • End Page

  • 205
  • Volume

  • 89
  • Issue

  • 1