Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior

Academic Article

Abstract

  • Social isolation during the juvenile critical window is detrimental to proper functioning of the┬áprefrontal cortex (PFC) and establishment of appropriate adult social behaviors. However, the specific circuits that undergo social experience-dependent maturation to regulate social behavior are poorly understood. We identify a specific activation pattern of parvalbumin-positive interneurons (PVIs) in dorsal-medial PFC (dmPFC) prior to an active bout, or a bout initiated by the focal mouse, but not during a passive bout when mice are explored by a stimulus mouse. Optogenetic and chemogenetic manipulation reveals that brief dmPFC-PVI activation triggers an active social approach to promote sociability. Juvenile social isolation decouples dmPFC-PVI activation from subsequent active social approach by freezing the functional maturation process of dmPFC-PVIs during the juvenile-to-adult transition. Chemogenetic activation of dmPFC-PVI activity in the adult animal mitigates juvenile isolation-induced social deficits. Therefore, social experience-dependent maturation of dmPFC-PVI is linked to long-term impacts on social behavior.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 28518236
  • Author List

  • Bicks LK; Yamamuro K; Flanigan ME; Kim JM; Kato D; Lucas EK; Koike H; Peng MS; Brady DM; Chandrasekaran S
  • Volume

  • 11
  • Issue

  • 1