Methylation Analysis of the Carbohydrate Portion of Carcinoembryonic Antigen

Academic Article

Abstract

  • The carbohydrate structural units of carcinoembryonic antigen samples isolated from four different tumors were quantitated using gas chromatography-mass spectrometery after methylation and subsequent conversion to their alditol acetates. Different carcinoembryonic antigen preparations showed some quantitative but no qualitative differences in the structural units present. The results indicate that a large portion of the fucose residues in the glycoprotein were linked to N-acetylglucosamine and that most of the branching mannose residues were probably linked to three N-acetylglucosamine residues. © 1976, American Association for Cancer Research. All rights reserved.
  • Authors

    Published In

  • Cancer Research  Journal
  • Author List

  • Coligan JE; Pritchard DG; Schnute WC
  • Start Page

  • 1915
  • End Page

  • 1917
  • Volume

  • 36
  • Issue

  • 6