Nodular sarcoidosis of the liver and spleen: Analysis of 32 cases

Academic Article


  • PURPOSE: To describe the computed tomographic (CT) appearance of nodular hepatosplenic sarcoidosis and its association with stage with chest radiography and clinical status. MATERIALS AND METHODS: Thirty-two patients (21 women, 11 men; aged 25-68 years) with nodular hepatosplenic sarcoidosis were evaluated. CT findings were described along with chest radiographic stage, clinical status, and level of angiotensin-converting enzyme (ACE). RESULTS: Nodules were small, multiple, and of low attenuation. Organomegaly was common. Abdominal adenopathy was present in 76% of the patients. Chest radiographs were normal in 25%; 61% had stage 1 or 2 radiographs. Abdominal or systemic symptoms were present in 66%. ACE level was elevated in 10 (91%) of 11 patients tested. No change in chest radiographic stage was noted in 74% of patients with follow-up radiographs. CONCLUSION: Nodular hepatosplenic sarcoidosis is associated with organomegaly, adenopathy, and symptoms. Nodules were not associated with advanced lung disease and did not herald a change in chest radiographic stage. An elevated ACE level may be helpful in diagnosis.
  • Authors

    Published In

  • Radiology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Warshauer DM; Molina PL; Hamman SM; Koehler RE; Paulson EK; Bechtold RE; Perlmutter ML; Hiken JN; Francis IR; Cooper CJ
  • Start Page

  • 757
  • End Page

  • 762
  • Volume

  • 195
  • Issue

  • 3