In vivo measurement of hepatic iodine concentration using fluorescent excitation analysis

Academic Article

Abstract

  • Hepatic iodine concentration was measured in the live dog by external use of fluorescent excitation analysis. The number of characteristic photons produced by interaction of exciting radiation from an americium-241 source with iodine within the tissue is proportional to the tissue iodine concentration. A correction is made for absorption of radiation by the abdominal wall and other tissues lying between the volume of liver being assayed and the detector collimator. The technique is applicable to the in vivo measurement of iodine concentrations from 0.05 to 40 mg/g. Accuracy of die technique is approximately ± 10%, which is within the range of variation in iodine concentration at various sites within the liver. Radiation dose is low, and radiolabeled tracer compounds need not be used. © Lippincott-Raven Publishers.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Koehler RE; Kaufman L; Brito A; Nelson JA
  • Start Page

  • 134
  • End Page

  • 137
  • Volume

  • 11
  • Issue

  • 2