A journey through the species barrier

Academic Article


  • The species barrier in prion infectivity is believed to reside in the degree of amino acid sequence heterology between the infectious prion protein, PrPSc, of the donor and the normal PrP of the host. Peretz et al. (2002) bring new evidence that distinct PrPSc species or prion strains may have different conformations even when they have identical amino acid sequence and that the conformation of the exogenous prion strain is a determinant of the species barrier in hosts that have identical PrP genotype.
  • Authors

    Published In

  • Neuron  Journal
  • Digital Object Identifier (doi)

    Author List

  • Chen SG; Gambetti P
  • Start Page

  • 854
  • End Page

  • 856
  • Volume

  • 34
  • Issue

  • 6