Potential long-term effect of tumor necrosis factor inhibitors on dementia risk: A propensity score matched retrospective cohort study in US veterans.

Academic Article


  • INTRODUCTION: Tumor necrosis factor (TNF) inhibitors are widely used to treat rheumatoid arthritis (RA) and their potential to retard Alzheimer's disease (AD) progression has been reported. However, their long-term effects on the dementia/AD risk remain unknown. METHODS: A propensity scored matched retrospective cohort study was conducted among 40,207 patients with RA within the US Veterans Affairs health-care system from 2000 to 2020. RESULTS: A total of 2510 patients with RA prescribed TNF inhibitors were 1:2 matched to control patients. TNF inhibitor use was associated with reduced dementia risk (hazard ratio [HR]: 0.64, 95% confidence interval [CI]: 0.52-0.80), which was consistent as the study period increased from 5 to 20 years after RA diagnosis. TNF inhibitor use also showed a long-term effect in reducing the risk of AD (HR: 0.57, 95% CI: 0.39-0.83) during the 20 years of follow-up. CONCLUSION: TNF inhibitor use is associated with lower long-term risk of dementia/AD among US veterans with RA.
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    Published In


  • Alzheimer's disease, US veterans, cohort study, dementia, long-term effect, rheumatoid arthritis, tumor necrosis factor inhibitor, Antirheumatic Agents, Arthritis, Rheumatoid, Dementia, Humans, Propensity Score, Retrospective Studies, Tumor Necrosis Factor Inhibitors, Veterans
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    Author List

  • Zheng C; Fillmore NR; Ramos-Cejudo J; Brophy M; Osorio R; Gurney ME; Qiu WQ; Au R; Perry G; Dubreuil M
  • Start Page

  • 1248
  • End Page

  • 1259
  • Volume

  • 18
  • Issue

  • 6