In recent years, the introduction and use of new nanomaterials in construction has increased at a rapid rate. Exterior surface paints have been a product that have had these nanomaterials added to them. In this study, the effects of natural weathering and exposure to atmospheric agents was examined to determine the detrimental effects on outdoor paint that has been created with nanomaterials. Data collected over the course of the yearlong study indicate that the nanoparticles of the titanium dioxide were eliminated rapidly. Further testing indicated that various elements of weathering were affecting the physical integrity of the paint. The weathering agents that appeared to have the greatest effect on the samples were acid deposition and total precipitation. There was a strong association between carbon monoxide and the effects on the panels. These results can lead to new plans for assessments involving the synergistic effects of all weathering agents.