Identification of the expressed sequence tags associated with childhood acute lymphoblastic leukemia at chromosome 6q16.3

Academic Article

Abstract

  • Objective: To identify the expressed sequence tags (EST) associated with childhood acute lymphoblastic leukemia (ALL) at chromosome 6q16.3, so as to clone candidate genes at the locus. Methods: The expression of EST at 6q16.3 in lymphocytes was detected using EST homology analysis in bioinformatics along with reverse transcription-polymerase chain reaction in 10 children with ALL and 5 healthy children. Results: The EST AA403058 expression decreased in seven of ten ALL children compared with that in healthy children (P < 0.001). Conclusions: The EST AA403058 expression is down-regulated in childhood ALL, suggesting it may be involved in the development of childhood ALL. This study provided important information toward cloning childhood ALL associated genes.
  • Author List

  • Kang R; Cao LZ; Xie M; Chen Y
  • Start Page

  • 147
  • End Page

  • 149
  • Volume

  • 7
  • Issue

  • 2