Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

Academic Article


  • Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens (NAc) of socially stressed mice but not of stress-naive mice. This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit. © 2014 Nature America, Inc.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Walsh JJ; Friedman AK; Sun H; Heller EA; Ku SM; Juarez B; Burnham VL; Mazei-Robison MS; Ferguson D; Golden SA
  • Start Page

  • 27
  • End Page

  • 29
  • Volume

  • 17
  • Issue

  • 1