Chemical constituents of Brazilian propolis and their cytotoxic activities

Academic Article


  • The EtOAc-soluble fraction of the MeOH extract of propalia afforded a new prenylated chromane derivative, 3-hydroxy-2,2-dimethyl-8-prenylchromane- 6-propenoic acid (1), along with 22 known compounds, 2-23. Of the known compounds, 4, 7, 12-19, and 22 were isolated for the first time from propolis, and the absolute configuration of 23 was established as (2S,3R). Investigation suggested that Baccharis spp. are a significant source of tropical Brazilian propalia, in addition to Clusia minor, Clusia major, and Araucaria heterophylla. All the compounds were tested for their cytotoxicity toward human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells. Among these compounds, 9 and 19-21 showed potent cytotoxicity, having ED50 values equal to or less than 10 μg/mL.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Banskota AH; Tezuka Y; Prasain JK; Matsushige K; Saiki I; Kadota S
  • Start Page

  • 896
  • End Page

  • 900
  • Volume

  • 61
  • Issue

  • 7