Hyponatremia secondary to reset osmostat in a child with a central nervous system midline defect and a chromosomal abnormality

Academic Article


  • A newborn with a CNS midline defect and persistent hyponatremia was diagnosed with a "reset" osmostat using a 3% hypertonic saline test. The diagnosis was established by measuring urinary arginine vasopressin (UAVP) and plasma osmolality (POsmol). In this infant a chromosome abnormality with the karyotype 46, X, -X, +der(X) t(X;13) (p22.1;q22) was associated with the midline defect and a reset osmostat.
  • Digital Object Identifier (doi)

    Author List

  • Gupta P; Mick G; Fong CT; Jospe N; McCormick K
  • Start Page

  • 1637
  • End Page

  • 1641
  • Volume

  • 13
  • Issue

  • 9