Randomized study of saquinavir with ritonavir or nelfinavir together with delavirdine, adefovir, or both in human immunodeficiency virus-infected adults with virologic failure on indinavir: AIDS Clinical Trials Group study 359

Academic Article


  • This study compared antiretroviral activity among 6 'salvage' therapy regimens. The study was a prospective, randomized, 2 x 3 factorial, multicenter study of the AIDS Clinical Trials Group. The study enrolled 277 human immunodeficiency virus (HIV)-infected patients naive to nonnucleoside analogues who had taken indinavir >6 months. The patients had 2000-200,000 HIV RNA copies/mL. Patients received saquinavir with ritonavir or nelfinavir together with delavirdine and/or adefovir and were followed for safety and antiretroviral response between baseline and week 16. At week 16, 30% (77/254) of patients had ≤500 HIV RNA copies/mL. Virologic response did not differ significantly between pooled ritonavir and nelfinavir groups (28% vs. 33%; P =. 50) or between pooled delavirdine and delavirdine/adefovir groups (40% vs. 33%; P =. 42). Pooled delavirdine groups had a greater virologic response rate than did adefovir groups (40% vs. 18%; P =. 002). Overall, one-third of patients who experienced virologic failure on an indinavir-containing regimen suppressed virus load levels while they were taking a new salvage regimen. © 2000 by the Infectious Diseases Society of America. All rights reserved.
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    Author List

  • Gulick RM; Hu XJ; Fiscus SA; Fletcher CV; Haubrich R; Cheng H; Acosta E; Lagakos SW; Swanstrom R; Freimuth W
  • Start Page

  • 1375
  • End Page

  • 1384
  • Volume

  • 182
  • Issue

  • 5