Characteristics of Central Visual Field Progression in Eyes with Optic Disc Hemorrhage

Academic Article


  • Purpose: To investigate the characteristics and rate of central visual field loss after optic disc hemorrhage (DH). Design: Prospective cohort study. Methods: Three hundred forty-three eyes of 220 subjects who had ≥3 years of follow-up with a minimum of 5 visits with 10-2 and 24-2 visual field (VF) were recruited. Rates of 10-2 mean deviation (MD) loss in each hemifield and predefined zones were compared using linear mixed-effects models in DH and non-DH eyes. Clustered pointwise regression analysis was also used to define central VF progressors and compared with 24-2 VF loss using guided progression analysis. Results: Thirty-nine eyes with DH and 304 eyes without DH had a mean follow-up of 5.2 years. Eyes with DH had rates of 10-2 MD loss that were 3 times faster than non-DH eyes (mean difference −0.36 dB/year [95% confidence interval 0.54-0.18]; P < .001) and were 3.7 times more likely to progress (P = .002). A larger proportion of glaucomatous eyes showed central VF progression rather than peripheral VF progression in the DH group (30.8% vs. 20.5%) compared with the non-DH group (10.9% vs. 9.2%). In early glaucoma, the rate of 10-2 MD loss was 5.5 times faster in DH eyes than in non-DH eyes (P < .001). Superonasal and superotemporal central VF regions progressed more rapidly than other regions, especially in DH eyes. Conclusion: Central VF loss is accelerated in glaucoma eyes with DH and it corresponds topographically to the DH location. In patients with glaucoma with DH, one should consider supplementing 10-2 VFs with 24-2 VFS to monitor the disease.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 2923758
  • Author List

  • David RCC; Moghimi S; Do JL; Hou H; Proudfoot J; Zangwill LM; Kamalipour A; Nishida T; De Moraes CG; Girkin CA
  • Start Page

  • 109
  • End Page

  • 119
  • Volume

  • 231