Cerebral invasive aspergillosis in a case of chronic lymphocytic leukemia with bruton tyrosine kinase inhibitor

Academic Article


  • Bruton tyrosine kinase (BTK) inhibitors have become an important therapy for untreated and previously treated patients with chronic lymphocytic leukemia (CLL). Despite improved outcomes, rare adverse events, such as invasive fungal infections, have been reported with the use of first-generation BTK inhibitors. Invasive fungal infections carry a high morbidity and mortality risk. There have been several case reports describing the association between aspergillosis and ibrutinib treatment, but none with acalabrutinib, to our knowledge. In this case report, we describe a patient with CLL who developed an intracranial Aspergillus fumigatus infection while receiving acalabrutinib.
  • Published In

  • Current Oncology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Alkharabsheh O; Alsayed A; Morlote DM; Mehta A
  • Start Page

  • 837
  • End Page

  • 841
  • Volume

  • 28
  • Issue

  • 1