Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes

Academic Article

Abstract

  • Liao et al. use mouse models to test a prenatal approach for correcting growth anomalies in two imprinting diseases, BWS and SRS. They find that cases where the fetal growth factor IGF2 is misregulated can be diagnosed, and growth can be corrected by prenatally adjusting IGF2 or its signaling output.
  • Authors

    Published In

  • Cell Reports  Journal
  • Digital Object Identifier (doi)

    Author List

  • Liao J; Zeng TB; Pierce N; Tran DA; Singh P; Mann JR; Szab√≥ PE
  • Volume

  • 34
  • Issue

  • 6