Central Visual Field Defects in Patients with Distinct Glaucomatous Optic Disc Phenotypes

Academic Article


  • Purpose: To investigate central visual field (VF) defects among 4 phenotypes of glaucomatous optic discs. Design: Cross-sectional study. Methods: Optic disc phenotypes were determined in eyes with definite or suspected glaucoma that had a 24-2 VF with mean deviation (MD) better than −12 dB and a 10-2 VF. 10-2 VFs were classified as abnormal based on a cluster criterion. Additionally, the average of the total deviation values at each 10-2 test point was compared by optic disc phenotype. Results: The following 4 glaucomatous optic disc phenotypes were identified in 448 eyes of 309 patients: focal ischemic (FI) (n = 121); generalized cup enlargement (GE) (n = 109); myopic glaucoma (MY) (n = 66); and senile sclerotic (SS) (n = 152). Although 24-2 VF MD values were similar among optic disc phenotypes, GE eyes had higher 10-2 VF MD (P =.004), as well as lower 24-2 VF pattern standard deviations (PSD) (P <.001) and VF 10-2 PSD (P <.001) than the other phenotypes. The prevalence of an abnormal VF 10-2 was highest in FI eyes (78.5%) and lowest in GE eyes (50.5%) (P <.001). In glaucoma suspects, the prevalence of an abnormal 10-2 VF was highest in the MY eyes (31.2%) and FI eyes (23.5%) and lowest in GE eyes (8.6%). In mild glaucoma, the prevalence of abnormal 10-2 VF test results was highest in FI eyes (79.2%) and lowest in GE eyes (44.4%) (P =.013). Conclusions: The severity and prevalence of central VF loss varied among different glaucomatous optic disc phenotypes. Glaucomatous eyes with FI and MY optic disc phenotypes are more likely to have 10-2 VF loss, particularly in early disease, and especially may benefit from testing with both 10-2 and 24-2 VF tests.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Ekici E; Moghimi S; Hou H; Proudfoot J; Zangwill LM; Do JL; Oh WH; Kamalipour A; Liebmann JM; De Moraes CG
  • Start Page

  • 229
  • End Page

  • 240
  • Volume

  • 223