Management of Trichomoniasis in the Setting of 5-Nitroimidazole Hypersensitivity

Academic Article


  • Metronidazole and other 5-nitroimidazoles are the mainstay of Trichomonas vaginalis treatment, with few efficacious and safe treatment options available outside of this class. Patients with trichomoniasis and a history of a clinically confirmed hypersensitivity reaction to 5-nitroimidazoles present a management challenge for clinicians. The first step in managing such patients is metronidazole desensitization. In situations where this cannot be performed or tolerated, treatment with alternative regimens outside of the 5-nitroimidazole class, such as intravaginal boric acid or paromomycin, may be possible.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Van Gerwen OT; Camino AF; Bourla LN; Legendre D; Muzny CA
  • Start Page

  • E111
  • End Page

  • E115
  • Volume

  • 48
  • Issue

  • 8