Cutaneous neoplasms composed of melanoma and carcinoma: A rare but important diagnostic pitfall and review of the literature.

Academic Article


  • We report two cases of combined cutaneous tumors composed of melanoma and carcinoma. The first tumor presented as a 5-mm pink-blue macule over the right zygomatic arch in an 85-year-old man. Shave biopsy and immunohistochemical studies revealed that the tumor was composed of melanoma (highlighted by SOX10 and MART-1, with high Ki-67 proliferative index) intermixed with nodular basal cell carcinoma (highlighted by pan-cytokeratin and Ber-EP4). The neoplastic melanocytes were confined to the basal cell carcinoma nodules, and a diagnosis of combined melanoma in situ and basal cell carcinoma was rendered. After therapeutic excision, the patient was disease-free at 9 months after the initial diagnosis. The second tumor presented as a 6-mm pink-brown crusted papule on the right forehead in an 89-year-old man. Shave biopsy and immunohistochemical studies revealed that the tumor was composed of malignant melanoma (MM) (highlighted by S100 and MART-1) intermixed with squamous cell carcinoma (SCC) (highlighted by cytokeratin and p63), and a diagnosis of combined MM-SCC was rendered. These two cases highlight the importance of recognizing these rare types of melanocytic-epithelial cutaneous neoplasms to arrive at an accurate diagnosis that may inform appropriate disease stage and therapy.
  • Authors

    Published In


  • basal cell carcinoma, combined tumors, melanoma, squamous cell carcinoma, Aged, 80 and over, Biomarkers, Tumor, Carcinoma, Basal Cell, Diagnosis, Differential, Humans, Male, Melanoma, Neoplasm Proteins, Neoplasms, Second Primary, Skin Neoplasms
  • Digital Object Identifier (doi)

    Pubmed Id

  • 812653
  • Author List

  • Mejbel HA; Nelson KC; Pradhan D; Ivan D; Zaleski M; Nagarajan P; Tetzlaff MT; Curry JL; Torres-Cabala CA; Prieto VG
  • Start Page

  • 36
  • End Page

  • 46
  • Volume

  • 47
  • Issue

  • 1