Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia

Academic Article


  • Ouellette et al. identify Dlgap2 as a potential modifier of working memory in an aged Diversity Outbred (DO) mouse population. The cross-species significance of this finding is highlighted by the association between human DLGAP2 and Alzheimer's disease phenotypes at the variant, gene expression, and methylation levels.
  • Published In

  • Cell Reports  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 21681179
  • Author List

  • Ouellette AR; Neuner SM; Dumitrescu L; Anderson LC; Gatti DM; Mahoney ER; Bubier JA; Churchill G; Peters L; Huentelman MJ
  • Volume

  • 32
  • Issue

  • 9