Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action

Academic Article


  • Here, Thielen et al. show that a newly designed, orally available small molecule inhibited pancreatic islet TXNIP expression, glucagon secretion, hepatic glucagon action, glucose production, and steatosis, and exhibited strong anti-diabetic effects in mouse models of type 1 and type 2 diabetes, promising a distinct and innovative diabetes treatment approach.
  • Published In

  • Cell Metabolism  Journal
  • Digital Object Identifier (doi)

    Author List

  • Thielen LA; Chen J; Jing G; Moukha-Chafiq O; Xu G; Jo SH; Grayson TB; Lu B; Li P; Augelli-Szafran CE
  • Start Page

  • 353
  • End Page

  • 365.e8
  • Volume

  • 32
  • Issue

  • 3