Feasibility of an HA2 domain-based periodontitis vaccine

Academic Article


  • In a rat periodontitis model, preinoculation with the Porphyromonas gingivalis HA2 binding domain for hemoglobin provided protection from disease. Protection was associated with induced anti-HA2 immunoglobulin G (IgG) humoral antibodies. The IgG subclass ratios suggested that relatively lower Th2/Th1-driven responses were directly associated with protection when rHA2 was administered in saline.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • DeCarlo AA; Huang Y; Collyer CA; Langley DB; Katz J
  • Start Page

  • 562
  • End Page

  • 566
  • Volume

  • 71
  • Issue

  • 1