Ig-Secreting and interferon-γ-producing cells in mice mucosally immunized with influenza virus

Academic Article


  • Oral immunization of mice with influenza virus type A/Udorn, induced antigen-specific IgA antibodies in external secretions (e.g., saliva and fecal extract). Increased numbers of antigen-specific IgA spot-forming cells (SFC) were seen in mononuclear cells isolated from IgA-effector tissues (e.g., SG) of mice orally-immunized with influenza virus. Following oral or systemic immunization of mice, IFNγ-secreting cells (Th1 type) displayed a characteristic pattern of distribution which was related to the route of immunization.
  • Author List

  • Novak M; Yamamoto M; Fujihashi K; Moldoveanu Z; Kiyono H; McGhee JR; Mestecky J
  • Start Page

  • 1587
  • End Page

  • 1590
  • Volume

  • 371
  • Issue

  • B