Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity

Academic Article


  • The eye is protected by the ocular immunosurveillance system. We show that tear duct-associated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), including the presence of M cells and immunocompetent cells for antigen uptake and subsequent generation of mucosal immune responses against ocularly encountered antigens and bacteria such as Pseudomonas aeruginosa. Initiation of TALT genesis began postnatally; it occurred even in germ-free conditions and was independent of signaling through organogenesis regulators, including inhibitor of DNA binding/differentiation 2, retinoic acid-related orphan receptor γt, lymphotoxin (LT) α1β2-LTβR, and lymphoid chemokines (CCL19, CCL21, and CXCL13). Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity. © 2009 Nagatake et al.
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    Author List

  • Nagatake T; Fukuyama S; Kim DY; Goda K; Igarashi O; Sato S; Nochi T; Sagara H; Yokota Y; Jetten AM
  • Start Page

  • 2351
  • End Page

  • 2364
  • Volume

  • 206
  • Issue

  • 11