Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire Development

Academic Article

Abstract

  • Innate-like B-1 B cells express canonical B cell receptors and originate through specialized developmental programs. Through immunoglobulin gene sequencing of single antigen-reactive B cells, New et al. demonstrate a significant role for environmental antigen-dependent selection events in shaping the GAC-reactive B-1 B cell clonal repertoire.

    • Authors

    Published In

  • Immunity  Journal

    • Digital Object Identifier (doi)

    Author List

  • New JS; Dizon BLP; Fucile CF; Rosenberg AF; Kearney JF; King RG

    • Start Page

  • 172

    • End Page

  • 186.e6

    • Volume

  • 53

    • Issue

  • 1