Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire Development

Academic Article


  • Innate-like B-1 B cells express canonical B cell receptors and originate through specialized developmental programs. Through immunoglobulin gene sequencing of single antigen-reactive B cells, New et al. demonstrate a significant role for environmental antigen-dependent selection events in shaping the GAC-reactive B-1 B cell clonal repertoire.
  • Published In

  • Immunity  Journal
  • Digital Object Identifier (doi)

    Author List

  • New JS; Dizon BLP; Fucile CF; Rosenberg AF; Kearney JF; King RG
  • Start Page

  • 172
  • End Page

  • 186.e6
  • Volume

  • 53
  • Issue

  • 1