CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia

Academic Article


  • In an in vivo CRISPR screen, Ramakrishnan et al. identify CXCR4 as a critical regulator of AML stem cells. Although the CXCR4 ligand CXCL12 is dispensable for leukemia development, CXCR4 signaling is essential for AML cells because it protects them from differentiation.
  • Published In

  • Cell Reports  Journal
  • Digital Object Identifier (doi)

    Author List

  • Ramakrishnan R; Peña-Martínez P; Agarwal P; Rodriguez-Zabala M; Chapellier M; Högberg C; Eriksson M; Yudovich D; Shah M; Ehinger M
  • Volume

  • 31
  • Issue

  • 8