Triple-Negative Breast Cancer (TNBC) is one of the most aggressive subtypes of breast cancer and tends to be of invasive ductal carcinoma histopathology. Less commonly found are Invasive Lobular Carcinomas (ILC) that are triple-negative. Various biological types of breast cancer have been identified through techniques, such as immunohistochemistry and gene profiling, which have helped to guide prognosis and treatment. To date, there have been no cases described as triplenegative (estrogen receptor-negative, progesterone receptor-negative, and human epidermal growth factor receptor-negative), Androgen Receptor (AR) positive, ILC that metastasized to the stomach, small bowel, bones, and dura mater. There are a few studies that report proximal small bowel metastasis in the setting of triple-negative, ILC; however, the AR status was not reported. We report a case of a 58-year-old Caucasian female diagnosed with de novo metastatic, triple-negative, AR-positive, ILC with multi-organ distant metastasis
