Sex differences in redox homeostasis in renal disease: Sex-differences in renal redox signaling

Academic Article


  • Sex differences in redox signaling in the kidney present new challenges and opportunities for understanding the physiology and pathophysiology of the kidney. This review will focus on reactive oxygen species, immune-related signaling pathways and endothelin-1 as potential mediators of sex-differences in redox homeostasis in the kidney. Additionally, this review will highlight male-female differences in redox signaling in several major cardiovascular and renal disorders namely acute kidney injury, diabetic nephropathy, kidney stone disease and salt-sensitive hypertension. Furthermore, we will discuss the contribution of redox signaling in the pathogenesis of postmenopausal hypertension and preeclampsia.
  • Published In

  • Redox Biology  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 3379658
  • Author List

  • Mitchell T; De Miguel C; Gohar EY
  • Volume

  • 31